Endocrine Abstracts

Introduction/Purpose: Despite some evidence that women with premature ovarian insufficiency (POI, loss of ovarian activity<40 years of age) are at risk for diminished life expectancy, large scale population-based studies are still scarce. The evidence on whether hormone replacement therapy (HRT) use decreases the mortality risk among women with POI are lacking. The aim of our study was to explore mortality among women with spontaneous POI and their controls in a large nati...

Introduction: Autoimmunity is an important etiological factor of premature ovarian insufficiency (POI, menopause <40 years). It has been estimated that 4-50 % of POI cases are of autoimmune origin. Only a few studies, with sample sizes of dozens to hundreds POI cases, have investigated the prevalence of autoimmune diseases in women with POI. We aimed to assess in an essentially larger data set the prevalence of severe autoimmune diseases treated in tertiary care prior to P...